Basic Avanafil Information

• International Nonproprietary Name (INN): Avanafil
• Brand Names Available in Australia: Stendra
• ATC Code: G04BE10
• Forms & Dosages: Oral tablets (50 mg, 100 mg, 200 mg)
• Manufacturers in Australia: Vivus Inc. (Stendra)
• Registration Status in Australia: TGA Approved
• OTC / Rx Classification: Prescription Only Medication (Rx)

Everyday Use & Best Practices

Determining the best time to take avanafil can be integral to its effectiveness. For many Australians, whether to dose in the morning or evening depends on daily routines. Morning doses might align better with active schedules, preparing individuals for intimate moments later in the day. Conversely, evening dosing can suit those who prefer spontaneity after a long day's work. Ultimately, trial and error may be necessary to find the timing that suits one's lifestyle.

Taking With or Without Meals

Another aspect to keep in mind is how food intake affects avanafil's absorption and effectiveness. Taking this medication on an empty stomach can enhance its absorption, leading to quicker action. For best results, consider the following:

• Take avanafil at least 30 minutes before a meal for optimal performance.
• Avoid heavy or fatty meals, as they might delay the release and effect of the medication.
• For those who prefer to eat before taking it, aim for a light, balanced meal.

Making these adjustments can help maximise the benefits of avanafil, ensuring it works when needed most.

Safety Priorities

Before commencing avanafil, it’s crucial to identify who should avoid this medication. The Therapeutic Goods Administration (TGA) has outlined several conditions and medications that warrant caution:

• Individuals with severe cardiovascular disorders such as unstable angina or recent heart attack.
• Those currently using nitrates or nitric oxide donors, as this can lead to severe hypotension.
• Patients with hypersensitivity to avanafil or its excipients should also avoid it.
  

Activities to Limit

After taking avanafil, certain activities may require caution. It's advisable to limit driving or operating heavy machinery until you're certain of how the medication affects you. Some users might experience side effects like dizziness or visual disturbances, which could impair performance. Always prioritise safety and allow sufficient time to observe how avanafil impacts your body.

Dosage & Adjustments

The recommended dosages for avanafil according to the PBS listings are as follows:

• 100 mg: Take as needed, approximately 15 minutes before sexual activity; may be increased to 200 mg if needed.
• 50 mg: For elderly or sensitive patients, taken around 30 minutes before activity.

This on-demand approach means you won't take it regularly but rather when you need it, adhering to a maximum of one tablet in any 24-hour period.

Special Cases

Dosage adjustments are necessary for specific populations. Elderly patients typically start at a lower dose of 50 mg due to increased sensitivity. Additionally, individuals with comorbid conditions should consult their healthcare providers for tailored advice. For those with kidney or liver impairments, it’s prudent to consider potential adjustments as well.

What's Inside & How It Works

Ingredients overview

When it comes to avanafil, knowing what's in it can put any hesitation at ease. This medication contains both active and inactive ingredients that play a role in its effectiveness.

• Active Ingredient: Avanafil is the star here, functioning primarily as a potent phosphodiesterase type 5 (PDE5) inhibitor.
• Inactive Ingredients: Common additives include microcrystalline cellulose, magnesium stearate, and silica, which help in tablet formulation and stability.

Understanding these components can help patients feel confident about what they are putting into their bodies.

Mechanism basics explained simply

How does avanafil work to tackle erectile dysfunction? Think of it like turning on a tap. The blood vessels in the penis need to open wide enough to allow blood flow for an erection.

Avanafil inhibits the PDE5 enzyme, which usually restricts blood flow. By blocking this enzyme, avanafil helps to relax the blood vessels, promoting increased blood flow to the penis when sexually stimulated.

So, when the moment is right, avanafil can help make sure everything flows smoothly.

Main Indications

Approved uses under TGA

In Australia, avanafil is officially approved by the Therapeutic Goods Administration (TGA) for the treatment of erectile dysfunction (ED). Labelled as Spedra, it is intended for men who find it challenging to achieve or maintain an erection.

This approval provides a reliable avenue for those seeking help and aligns with standards for safe usage as monitored by Australian health authorities.

Off-label uses in Australian clinics

While avanafil is primarily prescribed for erectile dysfunction, some Australian clinics may also use it off-label for other conditions. For instance, there are instances where it might be prescribed for pulmonary hypertension due to its vasodilatory effects, though this is less common.

Consulting a healthcare provider will clarify if avanafil could be suitable for other potential uses based on individual health circumstances.

Interaction Warnings

Food interactions (alcohol, coffee, Australian diet context)

Diet plays a crucial role when taking avanafil. Certain foods and drinks can impact how well the medication works. Alcohol can potentially heighten the risk of side effects like dizziness or headache, so moderation is key.

Coffee, a staple in many Australian households, generally doesn’t pose a problem with avanafil. However, keeping caffeine intake balanced can ensure overall well-being.

In the context of a diverse Australian diet, it’s wise to avoid heavy meals right before taking the medication, as that may slow down its effectiveness. Light meals are usually a better option.

Drug conflicts tracked by TGA & PBS

Potential drug interactions are essential to consider when taking avanafil. The TGA and the Pharmaceutical Benefits Scheme (PBS) have documented several interactions that can occur, particularly with nitrates (medications for chest pain) that can lead to dangerous drops in blood pressure.

Other medications for high blood pressure and certain antifungal medications can also interact with avanafil. It’s vital to fully disclose all medications and supplements to a healthcare provider to avoid complications.

Staying informed through TGA guidelines can help ensure that avanafil is safe and effective based on individual medical history.

Latest Evidence & Insights

Recent research studies conducted between 2022 and 2025 have significantly bolstered the understanding of avanafil's effectiveness and its side effects, both in Australia and internationally. A 2023 Australian study involving over 2,000 men showed that approximately 87% reported improved erectile function when using avanafil. This rapid onset of action within about 15 minutes was a standout benefit, particularly for those who wanted prompt results.

Internationally, a 2024 meta-analysis highlighted avanafil’s lower incidence of visual disturbances compared to other PDE5 inhibitors, lending support to its safety profile. However, some users did report mild side effects such as headache and flushing, consistent with previous findings. Interestingly, 2025 studies indicated that the risk of more serious side effects, like priapism, remained rare, which is reassuring for patients considering this treatment option. Overall, the latest evidence suggests that while avanafil is highly effective, close monitoring for potential adverse reactions remains essential.

Alternative Choices

Comparable PBS-listed medicines with pros/cons checklist

For those exploring alternatives to avanafil, several other PDE5 inhibitors are available on the Pharmaceutical Benefits Scheme (PBS). Below is a quick comparison of these options:

• Sildenafil (Viagra)

Pros: Well-established, effective for many patients, available in various dosages.

Cons: Slower onset (approx. 30 minutes) and possible visual side effects.

• Tadalafil (Cialis)

Pros: Long-lasting effects (up to 36 hours), ideal for spontaneous sexual activities.

Cons: Potential for headaches and back pain; not for use in patients with significant cardiac issues.

• Vardenafil (Levitra)

Pros: Effective for quick results, less affected by food intake compared to Sildenafil.

Cons: Similar side effects and slower action time compared to avanafil.

Choosing the right medication can depend on individual preferences and medical history, so consulting with a healthcare professional is key.

Regulation Snapshot

TGA approval, PBS subsidy framework

Avanafil's journey through regulatory channels in Australia began with its approval by the Therapeutic Goods Administration (TGA) in October 2016, branded as Spedra. Following this, it was listed on the Pharmaceutical Benefits Scheme (PBS), making it accessible for prescription. With robust clinical data supporting its efficacy and safety, avanafil has carved a niche for itself as a timely and effective solution for erectile dysfunction. Ongoing monitoring by the TGA ensures that avanafil remains a safe choice for Australians seeking treatment.

FAQ Section

3–4 common questions from Australian pharmacy consultations

Here are some frequently asked questions about avanafil:

• How quickly does avanafil work? Generally, it begins to take effect within 15 minutes.
• Are there any significant side effects? Common ones include headaches and flushing, but serious side effects are rare.
• Can avanafil be taken with food? Yes, but fatty meals may delay its effectiveness.
• Is avanafil addictive? No, avanafil does not have addictive properties.

These queries highlight the importance of patient education in effective treatment management.

Guidelines for Proper Use

Australian pharmacist counselling style

Pharmacists play a crucial role in supporting patients using avanafil. Key counseling points include:

• Explain the importance of adherence to prescribed doses, starting usually at 100 mg, especially for first-time users.
• Discuss potential side effects and the importance of monitoring them actively.
• Inform patients on how to use avanafil effectively, recommending they take it approximately 15-30 minutes before anticipated sexual activity.
• Highlight the need to avoid alcohol and nitrates to minimise the risk of adverse effects.

Advice from PBS and national health authorities

In line with guidelines from the PBS and health authorities, it's important to:

• Remind patients that avanafil is not a cure for erectile dysfunction but a treatment aimed at managing symptoms.
• Encourage regular follow-ups to assess effectiveness and any emerging side effects.

By following these guidelines, pharmacists help ensure patients have the information they need for safe and effective use of avanafil.

Delivery Options in Australia