Basic Diclofenac Information

• INN (International Nonproprietary Name): Diclofenac
• Brand Names Available in Australia: Voltaren, Clonac, Apo-Diclofenac, amongst others
• ATC Code: M01AB05
• Forms & Dosages: Tablets (25mg, 50mg, 75mg, 100mg), topical gel (1%, 2%, 3%), injections, and suppositories
• Manufacturers in Australia: Novartis, Sandoz, and Teva
• Registration Status in Australia: Approved by TGA for various indications
• OTC / Rx Classification: Available OTC in topical forms or Rx for oral/injectable forms

Everyday Use & Best Practices

Understanding the best times to take diclofenac can significantly enhance its effectiveness and manage pain better. For many, the routine varies significantly between morning and evening, influencing when to dose. In the morning, diclofenac can aid individuals facing a busy day, providing essential pain relief that aligns with daily activities. Taking it at this time can help combat discomfort and maintain productivity, particularly useful for those with chronic pain conditions. Evening doses might be more suitable for chronic conditions, allowing effective management of nocturnal symptoms, ensuring a restful night without interruptions from discomfort.

Taking With or Without Meals

The way food interacts with diclofenac can impact its absorption and potential side effects. Studies have shown that taking diclofenac with food may help reduce the chances of gastrointestinal discomfort. It’s advisable, particularly for those sensitive to medications, to consider meal timings when planning doses. Generally, if convenience permits, administering diclofenac after meals can optimise absorption while minimising side effects.

Who Should Avoid It (TGA Safety Notices)

The Therapeutic Goods Administration (TGA) provides clear guidelines about who should steer clear of diclofenac. This medication isn’t suitable for everyone. Here’s a rundown of conditions that make using diclofenac unsafe:

• Hypersensitivity to diclofenac or other NSAIDs
• Active gastric or duodenal ulcers
• Severe liver or kidney dysfunction
• Severe heart failure
• Pregnancy, particularly in the third trimester
• History of asthma or allergic reactions related to NSAIDs

Even if there are no apparent restrictions, it’s crucial to consult a healthcare professional before jumping on the diclofenac bandwagon. They can provide individualised advice based on personal health history. It’s just wise to check in with a doctor or pharmacist to avoid any nasty surprises.

Activities to Limit (Driving, Machinery, Workplace Safety)

When taking diclofenac, keeping safety in mind is essential. Some side effects may sneak up and catch users off guard, affecting both cognitive function and motor skills. Here are some recommendations regarding activities that require full concentration:

• Avoid driving or operating machinery if feeling drowsy or dizzy.
• Be cautious when performing tasks that require quick reactions.

Patients often report incidents of headache, dizziness, or even nausea after taking diclofenac. If these effects occur, they can significantly impair the ability to carry out everyday tasks safely. It’s worth noting that the incidence rate of these side effects can vary, but being aware and cautious can help prevent accidents. Safety first!

Dosage & Adjustments

General Regimen (PBS-Listed Guidelines)

The dosage of diclofenac varies depending on the condition being treated, following strict guidelines laid out in the Pharmaceutical Benefits Scheme (PBS) in Australia. Adhering to PBS recommendations is crucial, as each formulation of diclofenac has a tailored dose to maximise therapeutic effect while minimising potential risks. Here’s an overview:

• Osteoarthritis & Rheumatic Pain: 50mg – 100mg 2-3 times a day.
• Acute Pain: Single doses of 50mg – 75mg orally or via IM injection.
• Topical Use: Apply 2-4g of gel to the affected area 3-4 times per day.
• Ophthalmic Use: 1 drop in the affected eye 4-5 times a day, depending on specific indications.

Always ensure to follow the prescribed dosage, as exceeding the recommended limits can lead to serious side effects, including gastrointestinal issues and potential renal complications.

Special Cases (Elderly, Indigenous Health, Comorbidities)

Special populations may require adjusted dosages of diclofenac to accommodate their unique health needs.

For the elderly, start with the lowest effective dose, ensuring close monitoring for signs of gastrointestinal, renal, or cardiovascular complications, as they may be more susceptible to side effects.

In the realm of Indigenous health, it's essential to acknowledge cultural sensitivities when providing healthcare, including the prescription of diclofenac. Tailoring treatment involves understanding unique health conditions prevalent in these communities, and health practitioners should engage with Indigenous knowledge systems while considering traditional approaches alongside modern medical protocols.

For individuals with comorbidities, such as liver or kidney impairment, doses must be reduced or, in severe cases, avoided altogether. Regular assessments are critical to determine the best therapeutic regimen without exacerbating existing conditions.