Basic Testosterone Topical Information

• International Nonproprietary Name (INN): Testosterone
• Brand names available in Australia: Testogel, AndroGel, Tostran
• ATC Code: G03BA03
• Forms & dosages: Transdermal gel, patch, nasal gel, injectable
• Manufacturers in Australia: AbbVie, Endo International, Pfizer
• Registration status in Australia: Registered as prescription-only medication
• OTC / Rx classification: Prescription-only (Rx)

Everyday Use & Best Practices

The choice of when to apply topical testosterone often depends on individual preferences and daily routines across Australia. While some Australians prefer morning dosing, believing it aligns better with hormonal rhythms and daily activities, others opt for evening applications to avoid potential transfers to partners during the day. Here’s a breakdown of the pros and cons:

• Morning Dosing: Users may experience increased energy throughout the day and can establish a routine that fits their wake-up schedule.
• Evening Dosing: Those who worry about skin transfers prefer this method, allowing time for absorption during sleep.

Ultimately, the best practice is to remain consistent with whichever time is chosen to maintain stable testosterone levels. Patients should consider their lifestyle and how they feel most comfortable when deciding on the timing of application.

Taking With or Without Meals

When it comes to whether testosterone topical should be taken with or without meals, the impact on absorption can vary. Generally, food does not significantly affect the absorption of testosterone gels or creams, which is good news for users. However, certain guidelines can enhance effectiveness:

• For optimal results, applying testosterone on clean, dry skin after a shower can assist with absorption.
• Steering clear of strong topical moisturisers on the application site can ensure the testosterone penetrates the skin effectively.
• Although food isn't a major player in absorption, a balanced diet rich in healthy fats may support overall hormone levels.

Patients should be aware that some foods, particularly those high in saturated fats, may influence testosterone levels indirectly. Hence, discussing dietary habits during consultations can be beneficial. This practical advice encourages patients to adopt healthy lifestyles that complement their testosterone treatments effectively. For more detailed information on testosterone and diet, refer to trusted resources such as [Health Direct](https://www.healthdirect.gov.au/).

Safety Priorities

Concerns about safety often arise when considering testosterone topical products. Understanding potential risks and who should steer clear of these treatments is crucial. It's particularly important to heed advice issued by health authorities such as the TGA. This guidance typically covers contraindications relevant to various demographics, health conditions, and individual circumstances.

Who should avoid it (TGA safety notices)

The Therapeutic Goods Administration (TGA) outlines specific contraindications for testosterone topical applications. Certain individuals should consider alternative treatments or consult a healthcare provider before using these products, including:

• Those with known or suspected prostate or breast cancer due to the potential for adverse effects.
• Individuals who are pregnant or breastfeeding, as these treatments can pose teratogenic risks.
• Persons with hypersensitivity to testosterone or any components in the formulation.
• Those with severe heart, liver, or kidney issues should also exercise caution, given the risk of exacerbating these conditions.

Additionally, individuals with benign prostatic hyperplasia or a history of myocardial infarction or stroke should approach testosterone products carefully and seek medical advice.

Activities to limit (driving, machinery, workplace safety)

After applying testosterone topical treatments, certain activities may warrant caution, particularly those requiring high levels of focus or coordination. Driving and operating heavy machinery may become risky following application due to potential side effects such as dizziness or altered mood. Workplace safety hinges on being alert and stable; hence, it's advisable to refrain from these activities until assessing personal reactions to the treatment.

Furthermore, engaging in rigorous physical activity soon after application can lead to skin irritation or unwanted absorbance into the body. Patients should allow the product sufficient time to absorb before undertaking strenuous tasks. It's all about listening to the body and prioritising well-being.

Those using testosterone topical, particularly in a workplace setting, should consider how their treatment may influence day-to-day functions. Awareness around these safety priorities can help mitigate risks and foster a well-informed approach to testosterone therapy.

Dosage & Adjustments

General regimen (PBS-listed guidelines)

When considering testosterone topical therapy for conditions such as male hypogonadism, knowing the standard dosages outlined by the Pharmaceutical Benefits Scheme (PBS) is essential. For male hypogonadism, the following dosages are commonly recommended:

• Gel (1%/1.62%): Usually, 50 mg is applied once daily.
• Patch: One 2 mg or 4 mg patch should be applied nightly.
• Nasal gel: A total of 33 mg is often administered, which equals 11 mg from one actuation in each nostril three times daily.

These dosages can be adjusted according to individual clinical responses and serum testosterone levels, with further adjustments within a range of 40–100 mg recommended for daily gels. Regular monitoring ensures optimal therapeutic outcomes without excessive testosterone.

Special cases (elderly, Indigenous health, comorbidities)

Dosage considerations are critical for special populations when using testosterone topical forms. In the elderly, therapy should begin at the lowest dose, with careful monitoring for potential side effects such as cardiovascular issues and prostate complications. Indigenous Australians may also require tailored treatment plans, accounting for genetic and environmental factors affecting metabolism and overall health.

Those with comorbid conditions like diabetes, liver dysfunction, or a history of cardiovascular events must have their therapy closely supervised. Specific adjustments might include:

• Reduction in dosage to mitigate risk factors.
• Increased frequency of monitoring to observe any adverse reactions.